A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Nanotechnology gives A selection of chances to add to biology. In this article I will existing examples where by nanofabrication – the ability to make confined structures with Proportions at will – is employed to look at the biophysics of solitary molecules and cells. I will present some examples from our lab:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules
Like a individual, I contain the biblical assignment to discover and use almost everything in generation for the good thing about my neighbour. I don't knowledge any conflict concerning religion and science. On the contrary, my faith stimulates me to accomplish science, to get open up-minded in the world.’
Considering the fact that 2000, Dekker has shifted the primary concentration of his work in the direction of biophysics wherever he studies the Homes of solitary biomolecules and cells utilizing the applications of nanotechnology. This transformation of discipline was pushed by his fascination with the outstanding working of Organic molecular constructions, as well as through the prolonged-time period standpoint that a lot of intriguing discoveries is often predicted During this field.[5] Present lines of analysis in his biophysics group are while in the regions of:[six]
This yielded a breakthrough. Within just just a few months, we were being in the position to measure transportation via someone single-walled carbon nanotube. Based upon reduced-temperature experiments by a superb PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up genuine quantum wires with incredibly long (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
What distinguishes biology from chemistry is always that these components collectively make up a living technique. The trick of explained life, I believe, lies during the interactions, the interplay of Those people molecules. The big dilemma in regards to the origin of life continues to be unanswered. How did we at any time evolve from easy molecules in the extremely sophisticated units we see these days? We don't know. I need to work on these kinds of massive, open up questions.’
Nanopores stand for a sublime and versatile tool to evaluate one molecules. We investigate novel detection modes with good-point out nanopores in addition to numerous methods to cees dekker measure proteins with nanopores. Projects encompass the subsequent:
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Bulk-surface coupling identifies the mechanistic link involving Min-protein styles in vivo As well as in vitro
Screening pseudotopological and nontopological styles for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Nature Physics many thanks the anonymous reviewers for his or her contribution on the peer assessment of the operate.
One example is, we consider the nucleopore sophisticated, a gateway in between the mobile nucleus along with the cytoplasm. This is a very complicated procedure and for that reason tough to study inside of a cell, so we use biomimetics. We reconstruct holes and then insert unique aspects in the nucleopore complex to review transport by it at the single-molecule amount.’
It absolutely was a really exciting time, during which I obtained many support from Delft University of Technological innovation, where by I was a professor at time, And that i started off several collaborations with molecular biologists. That assisted me understand quite a bit.’