ceesdekker.net - An Overview
ceesdekker.net - An Overview
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‘The next is nanopores, which can be our oldest line of investigation and which has now resulted in DNA sequencers depending on nanopores. We pull personal DNA strands through a nanopore and can then go through off the nucleotide sequence. Very lately, we even managed to study out a single protein for The 1st time working with This method. But this line of analysis is not merely about building tools, but also about serious Organic queries.
Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.
‘It was simply a make any difference of finding up a e-book on cell biology and beginning to go through. I had originate from a entire world of ultra-superior vacuums, cryostats and quantum phenomena, and now I used to be Operating at room temperature with molecular biology kits.
I can hardly visualize how I, to be a geneticist, would manage to master essential physics, not to mention compete at the top. How did you go over it?
2010, formulated a new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into solid-state nanopores
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en achieved 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
Given that 2000 he moved to single-molecule biophysics and nanobiology, with investigate from DNA supercoiling scientific tests of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with micro organism on chip, although his greatest desire is while in the path of knowing artificial cells.
Movement-driven rotary motors for example windmills and h2o wheels travel functional processes in human society. Though samples of these types of rotary motors also feature prominently in cell biology, their synthetic construction in the nanoscale has remained tough. Below we display move-pushed rotary movement of the self-structured DNA nanostructure that may be docked on to a nanopore in a skinny stable-point out membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking onto the reliable-condition nanopore, and subsequently shows a sustained unidirectional rotary movement of up to twenty rev s−one.
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It was in the course of this period that Dekker completed investigation on magnetic spin devices and on sounds in superconductors and semiconductors.
In 1993 he was appointed as Affiliate Professor at Delft College of Technologies. From the mid-nineteen nineties Dekker and his group reached achievements with the discovery on the Digital properties of carbon nanotubes, the initial solitary-molecule transistor and various nanoscience.
1999, first measurement in the wavefunction of solitary molecular orbitals of ceesdekker.net carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof to get a new Luttinger description of interacting electrons in nanotubes
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of long-selection conformational changes in Mre11/DNA mend complexes; and to start with power measurements over a DNA molecule in a nanopore
Solid-point out nanopores have tested to be a surprisingly versatile probe for single-molecule analysis of DNA. I'll explain several of our modern results – especially DNA knots – along with our attempts to broaden the capabilities of solid-point out nanopores even even further, from the route of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.